Category: mGlu5 Receptors

´╗┐Amazingly, compound 24 gained back some PI5P4Kactivity with an IC50 of 26 activity, whereas it is unfavorable in the context of PI5P4Kactivity, which is in contrast to the high similarity of the two binding sites (Supporting Figure 7)

´╗┐Amazingly, compound 24 gained back some PI5P4Kactivity with an IC50 of 26 activity, whereas it is unfavorable in the context of PI5P4Kactivity, which is in contrast to the high similarity of the two binding sites (Supporting Figure 7). Similarly, compounds 26 and 27 introduce either a dimethylamine or a methoxy group, respectively, in the para-position […]